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Patient Research

Because of the close partnership between basic scientists and clinical researchers at the UC Davis Medical Center, we have many opportunities to study memory and plasticity in clinical populations. UC Davis LaMP members are actively studying memory in many patient groups, including Schizophrenia, Epilepsy, Alzheimer's Disease, Vascular Dementia, Autism, Fragile X Syndrome. Researchers also have the opportunity to study patients with focal lesions to the hippocampus, prefrontal cortex, and other specific brain regions.

Electroencephalogram (EEG)

Researchers at the Dynamic Memory Lab are using electrical activity recorded at the scalp to investigate the role of neural oscillations in memory. We have access to a BioSemi ActiveTwo recording system, which is capable of recording up to 280-channel EEG at 24-bit resolution.

fMRI

The Imaging Research Center has two locations: one on the UCD Medical Center campus in Sacramento that currently houses two research-dedicated whole-body MRI scanners — a 1.5T GE Signa MRI System and a 3T Siemens TIM Trio MRI System. The second location is in Davis and houses a new Siemens 64-channel 3 Tesla "Skyra" MRI System. A wide range of imaging studies are carried out in the IRC. The IRC supports basic science and clinical research that investigates the structure and function of the nervous system, including perceptual, motor and cognitive function using real-time functional imaging techniques, and research that investigates systemic physiology and morphology in health and disease.

tDCS

Researchers at the Dynamic Memory Lab are actively studying how transcranial electrical stimulation (tDCS/tACS) affects brain activity and memory. We have access to a MRI-compatible NeuroConn tDCS/tACS system and a NeuroElectrics EEG/tDCS/tACS system that is capable of simultaneous 32 channel EEG recording and 8 channel high-definition tDCS.

Electrocochleography (ECoG)

Through collaborations with epilepsy surgery centers at UC Davis, Stanford, and University of Texas at Houston, LaMP researchers are recording electrical activity directly from the human brain during learning and memory experiments.

Transcranial Magnetic Stimulation (TMS)

The TMS lab at the CMB includes a MAGSTIM Superapid TMS System, with a BrainSite Stereotaxic Alignment module which includes a position tracker and software for coregistration of the magnetic stimulating coil over target brain loci using either skull landmarks or information from magnetic resonance imaging (MRI) scans of the subject’s brain. A visual and auditory stimulation system and behavioral response and analysis system is in place in the lab.

Optogenetics

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Patient Research

Electroencephalogram (EEG)

fMRI

tDCS

Electrocochleography (ECoG)

Transcranial Magnetic Stimulation (TMS)

Optogenetics

DREADDS

Slice physiology

Single/multi-unit recordings

In vivo/in vitro 2-photon microscopy

Patient Research

Electroencephalogram (EEG)

fMRI

tDCS

Electrocochleography (ECoG)

Transcranial Magnetic Stimulation (TMS)

Optogenetics

DREADDS

Slice physiology ​

Single/multi-unit recordings

In vivo/in vitro 2-photon microscopy

Slice physiology