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Featured Publication - Oct 2020

10/31/2020

8 Comments

 
Task-specific Disruptions in Theta Oscillations during Working Memory for Temporal Order in People with Schizophrenia

​Liu, Xiaonan L., ... [Charan Ranganath, J. Daniel Ragland, Cameron S. Carter] ..., et al. "Task-specific Disruptions in Theta Oscillations during Working Memory for Temporal Order in People with Schizophrenia." Journal of cognitive neuroscience 32.11 (2020): 2117-2130.
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     Prior studies demonstrated that neural oscillations are enhanced during working memory (WM) maintenance and that this activity can predict behavioral performance in healthy individuals. However, it is unclear whether the relationship holds for people with WM deficits. People with schizophrenia have marked WM deficits, and such deficits are most prominent when patients are required to process relationships between items, such as temporal order.
     Here, we used EEG to compare the relationship between oscillatory activity and WM performance in patients and controls. EEG was recorded as participants performed tasks requiring maintenance of complex objects ("Item") or the temporal order of objects ("Order"). In addition to testing for group differences, we examined individual differences in EEG power and WM performance across groups. Behavioral results demonstrated that patients showed impaired performance on both Item and Order trials. EEG analyses revealed that patients showed an overall reduction in alpha power, but the relationship between alpha activity and performance was preserved. In contrast, patients showed a reduction in theta power specific to Order trials, and theta power could predict performance on Order trials in controls, but not in patients.
     These findings demonstrate that WM impairments in patients may reflect two different processes: a general deficit in alpha oscillations and a specific deficit in theta oscillations when temporal order information must be maintained. At a broader level, the results highlight the value of characterizing brain-behavior relationships, by demonstrating that the relationship between neural oscillations and WM performance can be fundamentally disrupted in those with WM deficits.
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8 Comments
Informatika link
1/2/2024 07:44:02 am

How does the study on schizophrenia patients' working memory reveal specific disruptions in theta oscillations during the maintenance of temporal order information?

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Kara Kitchen link
7/13/2024 05:33:52 pm

Hello nnice blog

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minoxidil link
5/26/2025 08:01:23 am

This study offers significant insights into the neural mechanisms underlying working memory deficits in schizophrenia. The distinction between general deficits in alpha oscillations and specific deficits in theta oscillations is particularly noteworthy. It raises important questions about the potential for targeted interventions that might enhance theta activity, especially in tasks requiring temporal order processing. Future research could explore whether training programs aimed at improving theta oscillations could lead to better cognitive outcomes for individuals with schizophrenia. Additionally, understanding the neurobiological basis of these disruptions could inform the development of biomarkers for cognitive deficits in psychiatric disorders.

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Çerkezköy Su Kaçağı Tespiti link
5/29/2025 01:08:56 am

Sıhhi tesisat, ısıtma sistemleri, su kaçağı tespiti, tıkanıklık açma ve daha birçok alanda uzman ekiplerimizle hizmet sunmaktayız.

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Avcılar su tesisatçısı link
5/29/2025 01:09:50 am

Avcılar su tesisatçısı hizmetlerimizle su kaçağı, tıkanıklık ve tesisat arızalarına hızlı ve ekonomik çözümler sunuyoruz.

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Döner merdiven link
5/30/2025 02:39:43 am

En iyi döner merdiven sistemleri

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helezon döner merdiven link
5/30/2025 02:48:52 am

En iyi helezon döner merdiven sistemleri

Reply
Oto paspas üretim makinaları link
5/30/2025 02:52:22 am

En iyi Oto paspas üretim makinaları

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